The Molecular Fountain of Youth: Re-Evaluating Metformin and Geroscience Through the Lens of Medical Humanities
DOI:
https://doi.org/10.68024/mypqnh20Keywords:
Metformin, Geroscience, Medical Humanities, Philosophy of Aging, BioethicsAbstract
For millennia, human culture framed the desire to transcend aging within mythic, theological, and literary archetypes, ranging from the Epic of Gilgamesh to the Faustian bargain. In contemporary medicine, this existential pursuit has shifted to molecular laboratories, where the discipline of geroscience seeks to intervene in fundamental biological mechanisms of decay. Metformin a widely prescribed, low-cost biguanide historically limited to managing type 2 diabetes mellitus has recently emerged as a primary artifact in this scientific transition. Operating at the boundary between mundane clinical therapeutics and anti-aging bio-transcendence, metformin’s repositioning as a geroprotective candidate offers a critical focal point for humanistic inquiry. This paper critically evaluates the biological claims surrounding metformin including AMP-activated protein kinase (AMPK) activation, mechanistic target of rapamycin (mTOR) inhibition, autophagic degradation, chromatin fragment dynamics, and epigenetic biological clocks by embedding them within theoretical frameworks of Medical Humanities, Philosophy of Science, and Bioethics. We analyze how biomedical discourses construct aging either as a natural teleological process or as a treatable pathology, examine the ethical implications of non-human primate research (such as the 40-month cynomolgus monkey trial), and deconstruct the socio-economic paradigm shift proposed by the Targeting Aging with Metformin (TAME) trial framework. By synthesizing empirical literature with critical theory, this study demonstrates how geroprotective science reflects evolving cultural anxieties surrounding mortality, social utility, and the ethics of bodily extension.
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Aedh, A. I., Al-Kuraishy, H. M., Shokr, M. M., Alruwaili, M., & Batiha, G. E. (2026). Concept and connotation of the geroprotective and anti-aging effects of metformin: From AMPK activation to SASP suppression. Molecular and Cellular Endocrinology, 618, Article 112802. https://doi.org/10.1016/j.mce.2026.112802 DOI: https://doi.org/10.1016/j.mce.2026.112802
Baars, J. (2012). Aging and the art of living. Johns Hopkins University Press. DOI: https://doi.org/10.1353/book.18096
Barzilai, N. (2017). Targeting aging with metformin (TAME). Innovation in Aging, 1(Suppl 1), 743. https://doi.org/10.1093/geroni/igx004.2682 DOI: https://doi.org/10.1093/geroni/igx004.2682
Caplan, A. L. (2005). Anti-aging science: Ethical, conceptual, and policy issues. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences, 36(2), 287–297. https://doi.org/10.1016/j.shpsc.2005.03.005 DOI: https://doi.org/10.1016/j.shpsc.2005.03.005
Charon, R. (2006). Narrative medicine: Honoring the stories of illness. Oxford University Press. DOI: https://doi.org/10.1093/oso/9780195166750.001.0001
Han, S. Y., Yadav, M. K., & Wang, J. H. (2026). Metformin for longevity and sarcopenia: A therapeutic paradox in aging. Biomedicines, 14(2), Article 376. https://doi.org/10.3390/biomedicines14020376 DOI: https://doi.org/10.3390/biomedicines14020376
Keys, M. T., Smith, R. J., & Taylor, L. N. (2025). Emerging uncertainty on the anti-aging potential of metformin. Ageing Research Reviews, 111, Article 102817. https://doi.org/10.1016/j.arr.2025.102817 DOI: https://doi.org/10.1016/j.arr.2025.102817
Kumazawa, T., Xu, Y., Wang, Y., Lee, J. W., O'Brien, T. C., Ho, C. K., & Zhang, L. (2026). Metformin inhibits nuclear egress of chromatin fragments in senescence and aging. Nature Aging, 6(2), 303–315. https://doi.org/10.1038/s43587-025-01048-0 DOI: https://doi.org/10.1038/s43587-025-01048-0
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023). Hallmarks of aging: An expanding universe. Cell, 186(2), 243–278. https://doi.org/10.1016/j.cell.2022.11.001 DOI: https://doi.org/10.1016/j.cell.2022.11.001
Manneh, J., Alasmar, M., & El Hajj, N. (2026). Metformin at the convergence of aging and longevity. Aging, 18(1), 970–990. https://doi.org/10.18632/aging.206407 DOI: https://doi.org/10.18632/aging.206407
Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomez-Cabrera, M. C., Viña, J., Roth, G. S., de Cabo, R., & Bernier, M. (2013). Metformin improves healthspan and lifespan in mice. Nature Communications, 4, Article 2192. https://doi.org/10.1038/ncomms3192 DOI: https://doi.org/10.1038/ncomms3192
Parish, A. J., Lord, S. R., & Turner, N. (2022). Metformin has heterogeneous effects on model organism lifespans and is beneficial when started at an early age in Caenorhabditis elegans: A systematic review and meta-analysis. Aging Cell, 21(12), Article e13733. https://doi.org/10.1111/acel.13733 DOI: https://doi.org/10.1111/acel.13733
Rose, N. (2007). The politics of life itself: Biomedicine, power, and subjectivity in the twenty-first century. Princeton University Press. DOI: https://doi.org/10.1515/9781400827503
Social Philosophy and Policy Foundation. (2007). Personal identity and bioethics. Cambridge University Press.
Wang, C. P., Lorenzo, C., Habib, S. L., Jo, B., & Espinoza, S. E. (2017). Differential effects of metformin on age related comorbidities in older men with type 2 diabetes. Journal of Diabetes and Its Complications, 31(4), 679–686. https://doi.org/10.1016/j.jdiacomp.2016.12.001 DOI: https://doi.org/10.1016/j.jdiacomp.2017.01.013
Yang, Y., Lu, X., Liu, N., Ma, S., Zhang, H., Zhang, Z., Yang, K., Jiang, M., Zheng, Z., Jiao, L., Hu, J., Li, Y., Yang, F., Pang, Y., Zhao, Y., & Liu, G. H. (2024). Metformin decelerates aging clock in male monkeys. Cell, 187(22), 6358–6378.e29. https://doi.org/10.1016/j.cell.2024.08.021 DOI: https://doi.org/10.1016/j.cell.2024.08.021
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Copyright (c) 2026 Sajib Kumar Das, Sadia Tabassum Jamy, Preetikana Sarker (Author)
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